2016-08-23_0001.jpg

Author: Dr Tim Bracey

2016-08-23_0001.jpg

Author: Dr Tim Bracey

2016-08-23_0001.jpg

Author: Dr Tim Bracey

2016-08-23_0001.jpg

Author: Dr Tim Bracey

2016-08-23_0001.jpg

Author: Dr Tim Bracey

2016-08-23_0001.jpg

Author: Dr Tim Bracey

2016-08-23_0001.jpg

Author: Dr Tim Bracey

FAP FGPs with dysplasia

Author: Dr Tim Bracey
25/07/2016                9:10 AM                Suffix - Tissue Types                                       HI019562Z/16
                                                                                                     - Not Fully Authorised -
          1 - Gastric Biopsy                                                       
  
  Report sequence 1                           Slides Issued                                                                       19/08/2016 13:01
                                                                                    By     Rubia Khan                                                             _CELLPATH () PC
NATURE OF SPECIMEN:
1.   Gastric body biopsy x 4.
CLINICAL DETAILS:
- FAP with rectal colitis.   - Multiple gastric polyps and ….. - …..[illegible] glandular - histology.
GROSS DESCRIPTION:
   Four biopsies, the largest measuring 3mm and the smallest 2mm.  
S4 1B NS DL

Fundic gland polyp

Authors:  Elliot Weisenberg, M.D. (see  Authors  page)  

Revised:  25 May 2016, last major update August 2012

Copyright:  (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search:  Fundic gland polyp
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Table of Contents
Definition / General  |  Case Reports  |  Gross Description  |  Gross Images  |  Micro Description  |  Micro Images
Definition / General
  • Single or multiple small (2 mm) polypoid projections in gastric fundus / body
  • Considered to be hamartomas or peculiar form of hyperplastic polyp
  • Either sporadic or associated with familial adenomatosis polyposis syndrome, tuberous sclerosis
  • Multiple polyps associated with proton pump inhibitors
  • Fundic gland cysts are associated with increasing periods of treatment with omeprazole for GERD, and with  H. pylori  eradication (Hum Pathol 2000;31:684)
  • In familial adenomatous polyposis syndrome, occur with increased frequency, 25% are dysplastic vs. 1% of sporadic fundic gland polyps (Am J Surg Pathol 1998;22:293)
  • Sporadic cases associated with loss of immunoreactivity for tuberin, a protein altered in tuberous sclerosis (Mod Pathol 2002;15:862)
  • Patients with 10+ polyps often have beta-catenin mutations (Mod Pathol 2002;15:718)
Case Reports
  • 27 year old man with familial adenomatous polyposis (FAP) and multiple gastric polyps (Case of the Week #389)
Gross Description
  • Minute mucosal bumps 1 - 5 mm, usually 1 - 20, may be part of diffuse fundic gland polyposis (100+ polyps)
Gross Images

Images hosted on other servers:

50 year old woman taking proton pump inhibitors for 10 years

Micro Description
  • Dilated glands / microcysts lined by fundic epithelium
  • Shorted foveola, increased smooth muscle in lamina propria, no proliferation of foveolar epithelium