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increased apoptosis in epithelium and lamina propria
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2016-08-30_0001.jpg
Author: Dr Tim Bracey
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22/08/2016 12:25 PM Suffix - Tissue Types HI022310Y/16
- Not Fully Authorised -
1 - Duodenal Biopsy
Report sequence 1 Typed 30/08/2016 12:06
By Dr C Holgate CELLPATH (Dr Holgate) PC
NATURE OF SPECIMEN: 2WW
1. D2 x 4.
CLINICAL DETAILS:
IDA. CLO.
GROSS DESCRIPTION:
Four biopsies measuring: largest 4mm, smallest 2mm.
s4 1B NSW PJ/ID
HISTOLOGY:
Reported by:
Clive. THere is increased apoptotic debris at the ends of duodenal villi. consider
drug related enteritis and correlate with clinical history. Similar
changes can be seen in colonic mucosa related to NSAID use. Does the
patient have diarrhoea? otherwise no villous atrophy, no increased IEL
or Giardia. TB
To:
Bracey Tim (PLYMOUTH HOSPITALS NHS TRUST);
Shepherd Neil.A (GLOUCESTERSHIRE HOSPITALS NHS FOUNDATION TRUST);
Would call that apoptotic personally! Certainly unusual but would be more so if at crypt bases – not in your photo.
Need to correlate with clinical – does she have diarrhoea? Does not look anything like coeliac so if symptomatic then would raise the possibility of a medication –associated “enteritis”. Otherwise I would just mention in passing.
Marco
Agree with Marco
Drugs every time…………..
Neil
Professor Neil A Shepherd, DM FRCPath
Professor of Gastrointestinal Pathology & Consultant Histopathologist
Gloucestershire Cellular Pathology Laboratory
Cheltenham General Hospital
Sandford Road
CHELTENHAM
Glos GL53 7AN
United Kingdom
Tel: 0044- (0)3004-223304
Mobile: 0044- (0)7785-562280
Fax: 0044- (0)3004-223318
E-mail (work): neil.a.shepherd@nhs.net
E-mail (home): neilxshepherd@gmail.com
