Pemphigus vegetans
HI008721/16
HI008721/16
HI008721/16
HI008721/16
HI008721/16
HI008721/16
C3
IgG
06/04/2016 10:00 AM Suffix - Tissue Types HI008721V/16
NATURE OF SPECIMEN:
1. 6mm punch right groin.
2. 6mm punch IMF.
CLINICAL DETAILS:
?Pemphgous vegetation.
FAO - Tim Bracey.
GROSS DESCRIPTION:
1. Punch biopsy measuring 6 x 6 x 6 mm.
S2 1B NSW AG/JH
2. Punch biopsy of skin 6 x 6 x 7 mm received fresh for IMF staining. RA 6/4/16
HISTOLOGY:
Pemphigus vegetans:
Rare (1-2% of pemphigus cases) variant of pemphigus vulgaris characterized by verrucous plaques in the flexural regions
Oral cavity is commonly affected; cerebriform or scrotal tongue is a diagnostic clue of early involvement
Reported in long standing nasal heroin abuse and with HIV+ patients
Pemphigus vegetans:
Supra basal acantholysis is subtle, masked by exuberant proliferation of squamous epithelium which may show pseudo epitheliomatous hyperplasia
Large intraepidermal microabscesses filled with eosinophils and occasional acantholytic keratinocytes
Intercellular deposits of IgG (a) and C3 (b) on direct immunofluorescence