Signet ring changes in gastric and colorectal biopsies
Despite these concerning features, both are from benign conditions. The first (Figure 1A) is from a fundic gland polyp in a patient on long-term proton pump inhibitor therapy. The gastric gland epithelial cells have exuberant cytoplasmic vacuolation which can be demonstrated using anti-H+ ATPase antibody immunohistochemistry and ABPAS to be parietal cells and to lack … Continue reading “Signet ring changes in gastric and colorectal biopsies”