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a potential pitfall to be aware of in head and neck FNAC practice • 70-year-old man  presents with a mass in left lateral zygoma. •On U/S there was a hypoechoic lesion in the left parotid 1.3 x 0.9 cm, and a further probable lymph node 0.5 cm in the left zygomatic area. •Following informed consent … Continue reading “Cytology Histology Correlation confirms an unusual variant of a common malignancy”

Pathologists often use immunohistochemistry (IHC) to confirm what we already know, or strongly suspect from the H&E slide. AI can now assist us in a similar way such as identifying a tiny focus of cancer in a gastric biopsy, for which we might use a cytokeratin immunostain for confirmation. Like IHC it will allow us … Continue reading “Artificial Intelligence versus immunohistochemistry”

The smoking gun?

Despite these concerning features, both are from benign conditions. The first (Figure 1A) is from a fundic gland polyp in a patient on long-term proton pump inhibitor therapy. The gastric gland epithelial cells have exuberant cytoplasmic vacuolation which can be demonstrated using anti-H+ ATPase antibody immunohistochemistry and ABPAS to be parietal cells and to lack … Continue reading “Signet ring changes in gastric and colorectal biopsies”

As a biologist first, with medicine as my second career I often think of resilience as it applies to the natural world. If humans were wiped out by a meteorite or a new pandemic tomorrow it wouldn’t take very long for vegetation to engulf our cities and erase the superficial evidence of centuries of modern … Continue reading “Some thoughts on resilience.”

I often use a “cars and roads”analogy to explain certain aspects of #digitalpathology . Large high throughput scanners can be compared to fast cars, but without good quality roads linking large cities (hospitals) they can gather dust in the garage.In this article, I explain that you don’t necessarily need a Porsche or a Lamborghini to … Continue reading “The nomadic digital pathologist”